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Vitamin E Fights Against Obesity-Related Liver Disease

Investigators at the Case Western Reserve University School of Medicine led by Danny Manor, an associate professor report that vitamin E supplementation can alleviate symptoms of obesity-related liver disease.

Nonalcoholic steatohepatitis  (NASH) is a common complication of obesity characterized by oxidative stress, inflammation, and fat accumulation in the liver. It is a severe form of nonalcoholic fatty liver disease that leads to tissue scarring, also known as cirrhosis. This condition eventually leads to liver failure and may progress to liver cancer. There is currently no known treatment for NASH, and it is one of the most common indications for liver transplantation.

The researchers report at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston that their findings could have a direct impact on the lives of 63 million Americans who are at risk for developing obesity-related liver disease.

The study involved mice that were genetically engineered to lose their ability to regulate the vitamin E levels in the body. They were observed to have increased oxidative stress, fat accumulation and other signs of liver injury. Manor reports that after vitamin E supplementation majority of NASH-related symptoms in the animals were averted, which confirmed the association between vitamin E deficiency and liver disease.

The authors believe that their findings may have a significant impact on public health since most US adults do not consume the recommended amount of vitamin E specified by the National Institute of Medicine, which is 15 milligrams a day. One can obtain  this nutrient from vegetable oils, leafy greens, fortified cereals, nuts and seeds.


American Society for Biochemistry and Molecular Biology. Vitamin E identified as potential weapon against obesity. ScienceDaily.

Posted in: News Briefs, Vitamin E, Vitamins and Minerals

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