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Grape Seed Extract Fights Kidney Disease Due to High-Fat Diets

Resveratrol is a chemical compound believed to have antioxidant properties, which protect the body from the damaging effects of free radicals. Resveratrol is a polyphenol found in grape seed and grape skin extracts that has been the subject of much research.

A recent study published in the journal Applied Physiology, Nutrition, and Metabolism demonstrates initial evidence that grape seed and skin extract (GSSE) could protect against kidney disease resulting from a high-fat diet.

Researchers at the Laboratory of Bioactive Substance at the Center of Biotechnology of Borj-Cedria (CBBC) in Tunisia used laboratory rats that were fed a high-fat diet to induce low-grade renal lipotoxicity (kidney damage due to excess lipids). The effects of the diet included elevations in plasma urea (a by-product of metabolism), abnormal appearance of protein in the urine (proteinuria), increased deposits of triglycerides and saturated fatty acids, prominent signs of oxidative stress, and reduced copper levels in the kidneys. They also found microscopic structural abnormalities in the kidneys.

The lab rats received 500 mg/kg body weight of GSSE, which is equivalent to 35g/day for a 70 kg human adult). The investigators found that after treatment, there was a partial reversal of changes in the kidneys, including reduced triglyceride deposition. Co-author Kamel Charradi, a researcher in the Center, reveals that obesity-induced kidney damage and proteinuria may be prevented by GSSE, suggesting its potential use as a preventive nutriceutical for high-risk patients. Their previous studies have shown the benefits of GSSE in fighting obesity, brain, kidney and heart disease.


Canadian Science Publishing. Grape seed and skin extract: A weapon in the fight against kidney disease caused by high-fat diets. ScienceDaily.

Posted in: Anti-inflammatory, Kidney Disease, News Briefs

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