Resveratrol Useful in Fighting Prostate Cancer
Prostate cancer causes more deaths from cancer than other types of tumors in men older than 75 years. It is usually treated with surgery and radiation therapy when it has not spread to other parts of the body, and with chemotherapy and hormone therapy when other organs have been involved. The chances of survival from this type of cancer depend on the stage of the disease and the general health of the patient, in addition to the availability of proper treatment.
A new study from the University of Missouri brings more hope to patients who are being treated for the disease. Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine reports that resveratrol, a compound commonly found in grape skins and red wine, can make prostate cancer more responsive to radiation therapy, and increase the patient’s chance of full recovery from even aggressive tumors.
Previous studies have suggested that resveratrol has several beneficial effects on health, including stroke prevention and heart health. Aside from these, scientists have also found that the grape compound can make cancer cells more susceptible to chemotherapeutic drugs. The new study suggests that when combined with radiotherapy, resveratrol also helps fight tumor cells.
The scientists found that resveratrol could boost the activity of two proteins which can kill prostate cancer cells. Prostate cancer cells have low levels of granzyme B and perforin (proteins), and when resveratrol was introduced to these cells, they found that up to 97% of the cells died following radiation therapy. This was much higher than that caused by radiation treatment alone.
More research is needed to establish its use in human clinical trials for the treatment of prostate cancer.
University of Missouri-Columbia. Compound in grapes, red wine could be key to fighting prostate cancer. ScienceDaily.